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Drug-induced cutaneous lupus erythematosus after 5 years of treatment with carbamazepine


European Journal of Dermatology. Volume 16, Number 3, 281-3, May-June 2006, Clinical report

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Author(s) : Paolo Amerio, Carmela Innocente, Claudio Feliciani, Domenico Angelucci, Domenico Gambi, Antonio Tulli

Summary : Drug-induced lupus is a disease, inducible by several drugs, that shares symptoms and laboratory characteristics with idiopathic lupus erythematosus. We report a case of carbamazepine-induced cutaneous lupus erythematosus which developed after 5 years of treatment in a patient who was on this medication because of an epileptic crisis after cranial trauma. Carbamazepine is a medication rarely implicated in drug-induced cutaneous lupus, moreover there are very few reports of such long periods between the start of therapy and the presentation of the clinical symptoms. We describe this case to emphasize the possibility of cutaneous lupus induction by carbamazepine even after many years of therapy.

Keywords : carbamazepine, drug-induced lupus erythematosus, drug-reaction

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