John Libbey Eurotext




DNA repair, a potential target for anticancer drug development
Bulletin du Cancer. Volume 93, Number 4, 124-44, Numéro hors-série, Avril 2006, Formation SFC
Résumé Article gratuit
Author(s) : Philippe Pourquier
Summary : Mechanisms of DNA repair play a crucial role in the preservation of genome integrity. They also allow to circumvent the damages induced by a large number of anticancer agents and thus contribute to clinical resistance to anticancer drugs. We describe here the origin of the main lesions occurring on the DNA molecule as well as the main mechanisms of DNA repair. We show in some examples how it may be possible to rationally inhibit the DNA repair pathways in order to improve the efficacy of the existing anticancer drugs.
Keywords : DNA damage, DNA repair, alkylating agents

DNA repair, a potential target for anticancer drug development