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Cytokines in atopic diseases: revisiting the Th2 dogma |
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European Journal of Dermatology. Volume 16, Number 2, 103-13, March-April 2006, Review article |
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 Free Article
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Author(s) : Emilie Mamessier, Antoine Magnan |
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Summary : In the field of allergic diseases, extensive research has demonstrated the implication of a strong T H2 activation that both initiates and maintains in situ inflammation with the help of T H2 cytokines. However, as anti-T H2 cytokines therapy is not sufficient to suppress the disease, a more complex immunological mechanism is suspected. In this review, we will revisit the T H2 dogma in allergic diseases, propose a possible implication of T H1 inflammation correlated with the severity of atopic disease, to conclude with the therapeutic solutions envisaged. |
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Keywords : AHR:, Airway Hyper Reactivity, BAL:, Bronchoalveolar lavage, BCG:, Bacilli Calmette Guerin, BHR:, Bronchial Hyper Reactivity, CCL-5:, CC chemokine ligand 5, CTACK:, Cutaneous T cell-Attracting ChemoKine, DC:, Dendritic cells, ELISA:, Enzyme Linked Immunosorbent Assay, FcεRI:, Fragment c of the Receptor I, FEV 1:, Forced Expiratory Volume in one second, GAPDH:, GlyserAldehyde-3-Phosphate DesHydrogenase, GM-CSF:, Granulocyte/Macrophage Colony Stimulating-Factor, ICAM:, intercellular adhesion molecule, IDEC:, Inflammatory Dendritic Epidermal Cell, IFN:, Interferon, Ig:, Immunoglobuline, IL:, Interleukine, IS:, Induced Sputum, LT:, Leukotrienes, MCD:, Mast Cell Degranulating peptide, MCP:, Monocyte Chemoattractant Protein, MHC:, Majeur Histocompatibility Complex, MIP-1α:, Macrophage Inflammatory Protein-1-alpha, mRNA:, messenger RiboNucleic Acid, PBMC:, Peripheral Blood Mononuclear Cells, PDGF:, Platelet-Derived Growth Factor, PNN:, Polynuclear neutrophils, RANTES:, Regulated on Activation, Normal T cell Expressed and Secreted, STAT:, Signal Transducers and Activators of Transcription, TARC:, Thymus and Activation Regulated Chemokine, TGF-β:, Transforming Growth Factor beta, T H:, T helper, TNF:, Tumor Necrosis Factor, VCAM:, Vascular Cell Adhesion Molecule, VIT:, Venom Immunotherapy |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés