John Libbey Eurotext




Heat shock preconditioning induces delayed neuroprotection: in vivo and in vitro effects on kainate-induced cell damage.
Epilepsies. Volume 17, Number 4, 249-55, Octobre-Novembre-Décembre 2005, Article original
Résumé Article gratuit
Author(s) : V Duveau, S Arthaud, A Rougier, G Le Gal La Salle
Summary : A variety of cerebral preconditioning stresses are able to trigger cellular and molecular events which can protect neurones against a subsequent more severe insult. This phenomenon, called “cerebral tolerance”, clearly evidences the existence of endogenous neuroprotective mechanisms. The aim of the present study was to find a non-invasive and physiological preconditioning stimulus able to induce such a phenomenon. Here we show that, both in vitro and in vivo, a moderate hyperthermic preconditioning significantly decreases subsequent kainic acid-induced neuronal cell loss. Neuroprotection occurs in a time window of about one week and peaks 3 days after pre-treatment. Unravelling the mechanisms of heat shock preconditioning–induced cerebral tolerance should lead to the development of new therapeutic strategies.
Keywords : epilepsy, neuroprotection, cerebral tolerance, hyperthermia, preconditioning, kainic acid, hippocampus

Heat shock preconditioning induces delayed neuroprotection: in vivo and in vitro effects on kainate-induced cell damage.