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Confirmation of the association between male pattern baldness and the androgen receptor gene


European Journal of Dermatology. Volume 15, Number 5, 339-40, September-October 2005, Genes and skin

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Author(s) : Etgar Levy-Nissenbaum, Michal Bar-Natan, Moshe Frydman, Elon Pras

Summary : Male pattern baldness (MPB) is a common phenomenon with a complex mode of inheritance. A recent report has implicated the androgen receptor gene in MPB, but this result has not been confirmed. We analyzed a silent polymorphism in the androgen receptor gene (AR) in a group of 41 bald males and 39 non-bald males, and found a significant association (p <\; 0.0026), thus confirming the previously reported association between MPB and the AR gene.

Keywords : male pattern baldness, androgen receptor, single nucleotide polymorphism

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