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Oncogenes and thyroid tumors

Bulletin du Cancer. Volume 92, Number 1, 37-43, Janvier 2005, Synthèse

Résumé

Summary

Author(s) : Ludovic Lacroix, Jean Charles Soria, Jean Michel Bidart, Martin Schlumberger , Institut Gustave-Roussy, 94805 Villejuif Cedex.

Summary : Papillary thyroid carcinomas are characterized in 70 % of cases by the presence of either a RET/PTC rearrangement, or an activating point mutation of RAS or BRAF genes that induce a constitutive activation of the MAP kinase pathway. Follicular carcinomas are characterized by the presence of a RAS mutation or of a PAX8-PPARγ rearrangement. Inactivating mutations of the p53 gene are found only in anaplastic thyroid carcinomas.

Keywords : thyroid carcinoma, oncogen

Pictures

Figure 1 Modèle de la tumorigenèse épithéliale thyroïdienne.N : thyrocyte normal ; AF : adénome folliculaire hypofonctionnel : μCP : microcancer papillaire ; CF : cancer folliculaire ; CP : cancer papillaire ; CA : cancer anaplasique.