John Libbey Eurotext




Lymphoma with large-plaque parapsoriasis treated with PUVA
European Journal of Dermatology. Volume 15, Number 4, 265-7, July-August 2005, Therapy
Free Article
Author(s) : Risa Tamagawa, Norito Katoh, Chihiro Shimazaki, Akira Okano, Shinya Yamada, Kaori Ichihashi, Koji Masuda, Saburo Kishimoto
Summary : We report on a 78-year-old Japanese woman with a 50-year history of large-plaque parapsoriasis that had evolved into cutaneous T-cell lymphoma. Her large-plaque parapsoriasis had been treated with psoralen plus ultraviolet A for 10 years. Subsequently an isolated nodule appeared on her right lower leg. Prior or concurrent patches or plaques were absent. Histology revealed a diffuse nonepidermotropic infiltrate of large lymphocytes in the dermis, which had enlarged nuclei and prominent nucleoli. A diagnosis of CD30 ^– cutaneous large T-cell lymphoma was made. Following systemic chemotherapy, there was clinical improvement. No evidence of recurrence or systemic lymphoma has subsequently been found.
Keywords : carcinogenesis, CD30 ^– cutaneous large T-cell lymphoma, large-plaque parapsoriasis, non-mycosis fungoides T-cell lymphoma, psoralen plus ultraviolet A

Lymphoma with large-plaque parapsoriasis treated with PUVA