John Libbey Eurotext




Cutaneous ulcerations on hands and heels secondary to long-term hydroxyurea treatment
European Journal of Dermatology. Volume 14, Number 5, 343-6, September-October 2004, Clinical report
Free Article
Author(s) : Sarah FRIEDRICH, Kerstin RAFF, Michael LANDTHALER, Sigrid KARRER
Summary : Hydroxyurea is a chemotherapeutic agent used to treat myeloproliferative disorders and other non-neoplastic conditions. Cutaneous side-effects have been described in long-term therapy with hydroxyurea and include xerosis, hyperpigmentation, skin atrophy, erythema, alopecia, skin tumours and ulceration of the skin, particularly of the legs. We present a 71-year old patient with chronic myelocytic leukemia (CML) who developed extremely painful ulcers on the hands and heels as well as skin tumours while on long-term therapy with hydroxyurea. The ulcers were resistant to therapy but healed three months after discontinuation of hydroxyurea therapy.
Keywords : chronic myelocytic leukemia (CML), cutaneous lesions, skin tumours, hydroxyurea

Cutaneous ulcerations on hands and heels secondary to long-term hydroxyurea treatment