John Libbey Eurotext




Perianal condyloma‐like lesions in multiple myeloma associated amyloidosis
European Journal of Dermatology. Volume 14, Number 3, 193-5, May - June 2004, Clinical report
Free Article
Author(s) : Alberto SCHIERA, Marco PINI, Pietro PIOLTELLI, Eugenio ROSSI, Maria Gabriella VALENTE, Dario CRIPPA
Summary : Systemic types of amyloidosis include those associated with plasma cell dyscrasia, as in multiple myeloma. Here we describe a 57‐year‐old woman who was diagnosed as having multiple myeloma IgG λ. Six months after the diagnosis of myeloma, mucocutaneous lesions began to develop, with ecchymoses in the body folds and eyelid and periorbital purpura. Pedunculated condylomatous tumours began to develop in the perianal area. The excisional biopsy of a perianal nodule revealed a faintly eosinophilic, amorphous material replacing almost the entire dermis, in association with ectatic, endothelial‐lined vascular spaces. The dermal deposits showed affinity with Congo Red stain. There were no histopathological features typical of condylomata acuminata. A diagnosis of cutaneous myeloma‐associated amyloidosis was established. To our knowledge, this is the second reported case of condyloma‐like perianal lesions in multiple myeloma‐associated amyloidosis.
Keywords : amyloidosis, myeloma, condyloma‐like, perianal

Perianal condyloma‐like lesions in multiple myeloma associated amyloidosis