John Libbey Eurotext




Distribution of an antifungal drug, itraconazole, in pathological and non‐pathological tissues
European Journal of Dermatology. Volume 14, Number 1, 24-7, January-February 2004, Investigative report
Free Article
Author(s) : Mariko SEISHIMA, Zuiei OYAMA, Makiko ODA, Shiomi ISHIGO
Summary : An antifungal drug, itraconazole (ITZ) is effective for chromomycosis patients, but the distribution of ITZ and its metabolite, hydroxy‐intraconazole (OH‐ITZ) is unclear in pathological tissues. This study investigated how much ITZ and OH‐ITZ accumulated in the lesional tissues of chromomycosis and non‐lesional skin after oral treatment with ITZ. We determined the concentrations of ITZ and OH‐ITZ in the lesional tissues of chromomycosis by Foncecaea pedrosoi and non‐lesional skin after oral treatment with a total dose of 2.3g of ITZ. ITZ concentration was significantly higher in pathological skin than non‐pathological skin. The ITZ concentration in the lesional tissues was higher in the central site than in the marginal site. No difference was seen in the OH‐ITZ concentrations among three skin parts, the center and the margin in lesional skin, and non‐lesional skin adjacent to the lesion. This study showed higher concentrations of ITZ in pathological tissues than in non‐pathological tissues.
Keywords : chromomycosis, drug concentration, Foncecaea pedrosoi , hydroxy‐intraconazole

Distribution of an antifungal drug, itraconazole, in pathological and non‐pathological tissues