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Differential modulation of interleukin‐6 expression by interleukin‐1β in neuronal and glial cultures |
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European Cytokine Network. Volume 14, Number 2, 97-102, April 2003, Original article |
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 Free Article
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Author(s) : Silvia Di Loreto, Rita Maccarone, Luigi Corvetti, Pierluigi Sebastiani, Daniela Piancatelli, Domenico Adorno |
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Summary : We analysed the specific effects of IL‐1β immunoneutralization on the expression of IL‐6 in different pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the IL‐1β‐deprivation signal induced a decrease in IL‐6 expression and release of normoxic neurones, it provoked an increase in IL‐6 protein in hypoxic neurones. Moreover, the direct correlation between IL‐1β and IL‐6, observed in normal and recovering neuronal cultures, was reversed in hypoxic conditions. These reversals were not observed in glial cells, in which IL‐1β immunosuppression led to a decrease in IL‐6 under all conditions considered. In conclusion, the IL‐1β modulates IL‐6 in different ways according to the ambient physiological or pathological conditions, and also acts via different mechanisms, depending on the cellular phenotype. |
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Keywords : IL‐1β, IL‐6, neurones, glia, hypoxia |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés