John Libbey Eurotext




Drug Hypersensitivity Syndrome in a West‐Indian population
European Journal of Dermatology. Volume 13, Number 5, 478-81, September 2003, Clinical report
Free Article
Author(s) : Philippe MULLER, Patrick DUBREIL, Antoine MAHÉ, Isabelle LAMAURY, Birgit SALZER, Jacqueline DELOUMEAUX, Michel STROBEL
Summary : Some studies have suggested an ethnic susceptibility to Hypersensitivity Syndrome. We did a 7‐year‐prospective study in Guadeloupe whose population is mainly of African ancestry, and has free access to modern care facilities. Most patients included were Afro‐Caribbeans (26\\28), and females (20\\28). However, ethnic distribution did not reach significant conclusions. Annual incidence rate was estimated at 0.9\\100,000. Medium incubation and duration were 33 and 66 days respectively. Two patients with grade 4 hepatitis died from the syndrome. Two thirds of the patients were given prednisone, which usually alleviated the systemic symptoms, but did not prevent their development (in 5 patients) nor death. Carbamazepine, allopurinol, and minocycline accounted for 2\\3 of the cases. Sixty four percent of the causative prescriptions were judged inappropriate. DHS appeared as the most frequent type of severe systemic drug reaction in this population, and may largely be prevented by rational prescribing.
Keywords : drug hypersensitivity syndrome, epidemiology, carbamazepine, allopurinol, minocycline

Drug Hypersensitivity Syndrome in a West‐Indian population