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Cutaneous and lingual papules as a sign of β2 microglobulin-derived amyloidosis in a long-term hemodialysis patient |
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European Journal of Dermatology. Volume 13, Number 4, 393-5, July 2003, Clinical report |
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 Free Article
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Author(s) : Takeshi UENOTSUCH, Shinichi IMAFUKU Masaharu NAGATA Hiromaro KIRYU Keisuke MORITA Tetsuya KOGA Masutaka FURUE |
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Summary : Although hemodialysis has permitted long-term survival of patients with renal failure, β2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by β2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-β2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of β2 microglobulin-derived amyloidosis. |
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Keywords : advanced glycation end products, cutaneous and lingual papules, β2 microglobulin-derived amyloidosis, lichenoid plaque type. |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés