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Combination of calcipotriol and clobetasol propionate as a premixed ointment for the treatment of psoriasis
European Journal of Dermatology. Volume 13, Number 4, 382-4, July 2003, Therapy
Free Article
Author(s) : Norito KATOH, Saburo KISHIMOTO
Summary : The treatment of psoriasis requires good compliance, efficacy and low toxicity because of its long-term course and wide distribution. The aim of the study was to compare the efficacy of a once daily application of calcipotriol alone or calcipotriol and a superpotent steroid in a premixed form in patients with psoriasis. The monotherapy group of 32 patients with stable plaque psoriasis received 0.005% calcipotriol alone once daily. The combination group of 29 patients was treated once per day with 0.004% calcipotriol/0.01% clobetasol propionate as a premixed ointment. Eruption score of truncal involvement was evaluated. The combination regimen was more efficacious than the monotherapy as evidenced by (1) more patients with at least 50% reduction in the eruption score after 2 weeks, (2) lower eruption score after 6 weeks and later, and (3) less adverse effects. The combined once-per-day application of 0.004% calcipotriol/0.01% clobetasol propionate as a premixed ointment is a promising regimen for psoriasis.
Keywords : psoriasis, calcipotriol, clobetasol, sequential therapy, mixed ointment

Combination of calcipotriol and clobetasol propionate as a premixed ointment for the treatment of psoriasis