John Libbey Eurotext




Cutaneous granulomas as the first manifestation of Hodgkin’s disease
European Journal of Dermatology. Volume 13, Number 3, 299-301, May 2003, Clinical report
Free Article
Author(s) : A. MACAYA, O. SERVITJE, A. MORENO, J. PEYRÍ
Summary : We report the case of a 64-year-old male in whom fever, cutaneous rash and hepatomegaly were the first manifestations of Hodgkin disease (HD). Histologically a dense lymphohistiocytic infiltrate with a granulomatous pattern was found in the skin infiltrate. A computed tomography scan revealed hepatosplenomegaly and a small retroperitoneal lymphadenopathy. An hepatic percutaneous biopsy showed a granulomatous infiltration with typical Reed-Sternberg cells. Cutaneous manifestations of HD are briefly reviewed. The authors underline that granulomatous infiltration of the skin as the first manifestation of lymphoma is a very rare feature. We also discuss the possible pathogenic mechanisms of skin granulomas.
Keywords : cutaneous rash, familial Hodgkin disease, granulomas, Hodgkin disease, lymphoma

Cutaneous granulomas as the first manifestation of Hodgkin’s disease