John Libbey Eurotext




Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation
European Journal of Dermatology. Volume 13, Number 3, 254-7, May 2003, Investigative report
Free Article
Author(s) : Martin KUCHAREKOVA, Wynand H.P.M. VISSERS, Joost J. SCHALKWIJK, Peter C.M. van de KERKHOF, Peter G.M. van der VALK
Summary : The exact role of epidermal fatty acid binding protein (E-FABP) in skin is unknown. A restoration of the barrier function may be associated with an upregulation of E-FABP. Moreover, E-FABP is upregulated in a variety of cells in response to oxidative stress. A recent observation that dithranol induced irritation is not associated with skin barrier impairment prompted us to investigate the expression of E-FABP in this skin condition to elucidate the unknown function of this protein in skin. This study shows lack of E-FABP upregulation after a single application of dithranol on uninvolved skin of patients with psoriasis. The expression of E-FABP in dithranol irritation correlates with the unimpaired skin barrier function as assessed by measurements of TEWL. Furthermore, we did not find evidence for the recently introduced hypothesis that E-FABP functions as an antioxidant protein in the skin irritation induced by dithranol as oxidative stressor.
Keywords : anthralin, dithranol irritation, E-FABP, oxidative stress, skin barrier

Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation