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Naloxone per os in the treatment of opioid-induced constipation: case report of a patient resistant to conventional therapeutic


Journal de Pharmacie Clinique. Volume 21, Number 2, 109-14, Juin 2002, Pharmacothérapie

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Author(s) : H. CHEKROUD, S. SOYEZ, A. HERBAUT, M. DELERUE, P. SAUNIERE, D. MALLET, M. HOUILLEZ, T. DINE

Summary : The opioid-induced constipation in palliative care is an important worry for the patient, nurses and physicians. The usual laxative's treatments can be powerless to relieve a patient. The help of specific antagonist of morphine (naloxone) might to improve the situation considerably. Through a clinical observation and review of literature, this paper deals with the way of using naloxone per os.

Keywords : opioid-induced constipation, specific antagonist of morphine, palliative care.

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