John Libbey Eurotext




Hematopoietic progenitors of T lymphocytes
Hématologie. Volume 3, Number 5, 423-30, Septembre-Octobre 1997, Mini-revues et revues
Résumé Article gratuit
Author(s) : Anne Galy, Franck Morel
Summary : Because of their importance in the immune system, T lymphocytes are one of the most extensively characterized lineage of hematopoietic cells at the molecular and cellular level. In spite of this, there is relatively little information about the early stages of hematopoietic production of T lymphocytes. In order to define the phenotype and functional properties of hematopoietic progenitors of T cells, we have studied various populations expressing the cell surface molecule CD34. Such CD34+ progenitor cells have been isolated from bone marrow using flow cytometry and their biological properties such as thymus or marrow multilineage repopulating activity have been measured. In humans as in mice, it is possible to identify in bone marrow, T cell progenitors that express CD34 but are phenotypically and functionally distinct from hematopoietic stem cells. Identification of such intermediate stages of differentiation between stem cells and T cells is useful for mapping steps of differentiation and it provides the requisiste elements for the study of lymphoid production at a central level.
Keywords : T cells, B cells, NK cells, dendritic cells, hematopoietic cells CD34+.

Hematopoietic progenitors of T lymphocytes