John Libbey Eurotext




Consequences of prolonged epileptic seizures on cerebral development: relation between the initial insult and the development of temporal lobe epilepsy
Epilepsies. Volume 13, Number 3, 147-58, Juillet - Août - Septembre 2001, Articles originaux
Résumé Article gratuit
Author(s) : Céline Dubé, Astrid Nehlig
Summary : The relation between the occurrence of early epileptic seizures and the development of hippocampal sclerosis and temporal lobe epilepsy remains to be understood. It seems that only a small percentage of infants and children subjected to prolonged febrile convulsions later develop temporal lobe epilepsy. This population could present some risk factors, such as preexisting hippocampal lesion or a genetic sensitivity. The objective of this review is to summarize the state of the art on this subject; using the data from clinical and mainly experimental research. The review is mainly centred, on a model of status epilepticus whose consequences are studied in the immature and adult rat and which leads to the genesis of temporal lobe epilepsy only in the adult rat on one hand and on the other hand, on an experimental model of prolonged febrile convulsions. The discussion is set upon the opennings of the present data from the literature and the necessity to associate various factors in an effort to clarify the relationship between the initial insult and the genesis of temporal lobe epilepsy.
Keywords : status epilepticus, epilepsy, lithium-pilocarpine, development, lesions, rat.

Consequences of prolonged epileptic seizures on cerebral development: relation between the initial insult and the development of temporal lobe epilepsy