John Libbey Eurotext




Diffuse large B-cell lymphoma associated with skin, muscle and cranial nerve involvement
European Journal of Dermatology. Volume 10, Number 4, 306-8, June 2000, Cas cliniques
Free Article
Author(s) : Yasuyuki AMO, Ryoji TANEI, Kohzoh YONEMOTO, Kensei KATSUOKA, Mayumi MORI
Summary : The present case, a 75-year-old man with extranodal B-cell lymphoma showed facial hemiplegia, paresthesia and cutaneous manifestations. He was initially diagnosed as having a facial paralysis of unknown etiology. One month after the original diagnosis, erythematous indurated plaques developed on his left cheek and nose. A skin biopsy from the plaque on his cheek showed dense infiltrates of large lymphocytes with irregularly shaped nuclei and prominent nucleoli in the dermis and subcutaneous tissue. The lymphocytes were positive for L26 and CD79a. A diagnosis of diffuse large B-cell lymphoma was made. A muscle biopsy from facial muscle in the area of the erythematous plaque showed massive destruction of the muscle tissues by the lymphomatous infiltrates. Furthermore, electrodiagnostic study showed peripheral cranial nerve palsies, involving the left facial and trigeminal nerves. We conclude that diffuse large B-cell lymphoma may develop symptoms such as facial hemiplegia and paresthesia prior to cutaneous manifestations. Diffuse large B-cell lymphoma must be considered as one of the important causes of palsies of cranial nerves at the peripheral level.
Keywords : diffuse large B-cell lymphoma, facial hemiplegia, peripheral nervous system.

Diffuse large B-cell lymphoma associated with skin, muscle and cranial nerve involvement