John Libbey Eurotext




Pre-Kaposi’s sarcoma: an expansion of the spectrum of Kaposi’s sarcoma lesions
European Journal of Dermatology. Volume 9, Number 6, 480-2, September 1999, Cas cliniques
Free Article
Author(s) : T. Simonart, G. De Dobbeleer, M.-O. Peny, I. Fayt, D. Parent, J.-P. Van Vooren, J.-C. Noel
Summary : We report on a lymphoedematous form of classic Kaposi’s sarcoma (KS) in which characteristic purplish lesions were surrounded by atypical oedematous, flesh-coloured papules. Histological examination of these papular lesions revealed a proliferation of grouped, rather thick-walled capillaries with inflammatory infiltrates. Hot-start PCR amplification with KS 330-233 primer sequences demonstrated the presence of human herpesvirus 8 (HHV-8) sequences. In addition, cells isolated from these oedematous papules showed morphological and immunohistochemical features similar to those reported for KS-derived spindle cells. As a whole, these results suggest that these oedematous papular lesions represent pre-KS lesions and may expand the clinico-pathological spectrum of KS. The role of oedema in their induction is discussed.
Keywords : human herpesvirus 8, Kaposi’s sarcoma, oedema, proliferation, tumorigenesis.

Pre-Kaposi’s sarcoma: an expansion of the spectrum of Kaposi’s sarcoma lesions