John Libbey Eurotext




Subcutaneous nodules following treatment with aluminium-containing allergen extracts
European Journal of Dermatology. Volume 11, Number 2, 138-40, March - April 2001, Cas cliniques
Free Article
Author(s) : Eduardo NAGORE, Jorge A. MARTINEZ-ESCRIBANO, Agustin TATO, Vicente SABATER, Juan J. VILATA
Summary : We describe two patients who developed multiple itching nodules following immunization with vaccines adsorbed on aluminium hydroxide. Both patients had been treated with vaccines for extrinsic asthma and rhinitis for 4 and 10 years respectively. The lesions were persistent and lasted for several years. Histopathological findings were those of a foreign body reaction. Aluminium was most probably involved in the pathogenesis of these lesions because its presence could be demonstrated in macrophages using energy-dispersive X-ray microanalysis. Although some symptomatic relief was achieved with topical corticosteroids and oral antihistamines, treatment was unsuccessful.
Keywords : subcutaneous nodules, aluminium hypersensitivity, hyposensitization.

Subcutaneous nodules following treatment with aluminium-containing allergen extracts