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Delayed adverse reaction to sodium ioxaglic acid-meglumine |
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European Journal of Dermatology. Volume 11, Number 2, 134-7, March - April 2001, Cas cliniques |
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 Free Article
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Author(s) : Gisèle KANNY, Béatrice MARIE, Bruno HOEN, Philippe TRECHOT, Denise A. MONERET-VAUTRIN |
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Summary : A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix®). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine. |
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Keywords : contrast media, delayed adverse reaction, drug hypersensitivity, eosinophilia, hepatitic cytolysis, maculopapular rash. |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés