John Libbey Eurotext




Unlikely role of Epstein-Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma
European Journal of Dermatology. Volume 11, Number 3, 203-8, May - June 2001, Revues
Free Article
Author(s) : I. Hellier, O. Dereure, M. Segondy, B. Guillot, P. Baldet, J.J. Guilhou
Summary : Background: Primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) is a rare subset of cutaneous lymphoma, with a much better prognosis than its nodal counterpart. The pathogenesis of both nodal and primary cutaneous CD30+ ALCL is largely unknown but experimental data support the hypothesis that the Epstein-Barr virus could play a role in the nodal subset. Objective: To evaluate the involvement of Epstein-Barr Virus (EBV) in primary cutaneous CD30+ ALCL by searching for both nucleic acids and EBV proteins in cutaneous lesions. Setting: Two University Hospitals in Southern France (secondary referral hospitals). Patients: Eight consecutive patients with typical primary cutaneous CD30+ anaplastic large cell lymphoma were studied. Methods: Search for the presence of DNA, RNA and EBV proteins in cutaneous lesions by PCR, in situ hybridization and immunohistochemistry. Results: EBV DNA and RNA was identified in only one lesion of primary cutaneous CD30+ ALCL and in none of the normal adjacent skin samples. In situ hybridization and immunohistological studies were consistently negative in all samples. Conclusion: These results do not support an early role of EBV in the oncogenetic pathogenesis of primary cutaneous CD30+ ALCL.
Keywords : anaplastic large cell lymphoma, CD30, Epstein-Barr virus.

Unlikely role of Epstein-Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma