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CD4+CD25+ T cells as key regulators of immune responses |
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European Journal of Dermatology. Volume 13, Number 2, 111-6, March - April 2003, Revues |
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 Free Article
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Author(s) : Bertrand DUBOIS, Ludivine CHAPAT, Anne GOUBIER, Dominique KAISERLIAN |
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Summary : Discredited a few years ago, active suppression is now commonly considered as a key mechanism avoiding auto-reactivity and development of potentially harmful immune responses, and in some circumstances, as an obstacle to successful vaccination. A large quantity of literature identifies naturally occurring CD4+CD25+ T cells as key suppressor cells involved in the control of many pathophysiological diseases. Manipulation of these cells and control of their function offers new perspectives for the treatment of auto-immune and inflammatory diseases and enhancement of vaccine efficacy. Such clinical interventions require a better understanding of the conditions of expansion/activation of CD4+CD25+ T cells and deciphering of their mechanism of suppression, which remains incomplete and sometimes controversial. |
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Keywords : regulatory cells, CD4+CD25+, suppression, inflammation |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés