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Nitrendipine-induced subacute cutaneous lupus erythematosus |
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European Journal of Dermatology. Volume 13, Number 2, 213-6, March - April 2003, Cas cliniques |
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 Free Article
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Author(s) : Angelo V. MARZANO, Alessandro BORGHI, Maurizio MERCOGLIANO, Maura FACCHETTI, Ruggero CAPUTO |
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Summary : A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed. |
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Keywords : antiphospholipid syndrome, drug-induced subacute cutaneous lupus erythematosus, nitrendipine |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés