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Initially localized bullous pemphigoid at the irradiation site of breast carcinoma


European Journal of Dermatology. Volume 9, Number 2, 139-41, March 1999, Votre diagnostic !

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Author(s) : Uta Jappe, Bernd Bonnekoh, Harald Gollnick

Summary : A 78 year-old women was admitted in April 1998 with a seven month history of erosions on the right thorax. In 1994, she had undergone surgery at this site for an infiltrating duct carcinoma of the right breast (stage pT2N0G3) and afterwards had received radiotherapy at a total energy dose of 50 Gy. She then came to us for clinical investigations as she was suspected of having chronic radiodermatitis. The dermatological examination revealed large erosions on the lateral aspect of the mamma with haemorrhagic crusts surrounded by erythema and a few clear blisters at the margin (Figs. 1 and 2). Histological examination of one lesion (Fig. 3) revealed a subepidermal blister with a moderately dense, upper dermal infiltrate composed of neutrophils, abundant eosinophils, some mononuclear cells and a relatively high number of plasma cells.

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