John Libbey Eurotext




Lysine acetylsalicylate decreases proliferation and extracellular matrix gene expression rate in keloid fibroblasts in vitro
European Journal of Dermatology. Volume 12, Number 3, 231-5, May - June 2002, Rapports d'investigature
Free Article
Author(s) : Jean-Bernhard PETRI, Uwe-Frithjof HAUSTEIN
Summary : Background: In genetically predisposed individuals keloids are formed as benign collagenous tumors. Objective: The purpose of this study was to investigate whether the proliferation and matrix gene expression of keloid fibroblasts is differently influenced by the anti-inflammatory active drug lysine acetylsalicylate (LAS) when compared to normal skin fibroblasts in vitro. Methods: Normal skin and keloid fibroblasts derived from human donors were compared. Results: Excessive scarring and the formation of keloids are (at least in part) due to an overproduction of collagen types I and III. The results show a significant dose-dependent anti-proliferative effect of lysine acetylsalicylate. At the level of gene expression we observed a pronounced inhibitory effect of LAS on procollagen I and III mRNA synthesis, whereas matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 were not altered. Conclusions: Further clinical studies are planned to evaluate these effects of a high-dose treatment of keloids with LAS.
Keywords : Aspisol, fibroblast proliferation, keloid, lysine aspirin, mRNA analysis, scar formation, wound healing

Lysine acetylsalicylate decreases proliferation and extracellular matrix gene expression rate in keloid fibroblasts in vitro