John Libbey Eurotext




High-concentration (20 mug/g) tacalcitol ointment therapy on refractory psoriasis vulgaris with low response to topical corticosteroids
European Journal of Dermatology. Volume 12, Number 6, 553-7, November - December 2002, Thérapie
Free Article
Author(s) : Ichiro KATAYAMA, Akira OHKAWARA, Muneo OHKIDO, Shotaro HARADA, Kunihiko TAMAKI, Hidemi NAKAGAWA, Yoshiaki HORI, Shigeo NISHIYAMA
Summary : The efficacy and safety of the application of high-concentration (20 mug/g) tacalcitol ointment once daily for 12 weeks to psoriasis vulgaris lesions which showed low response to topical corticosteroids, were evaluated in a prospective, multicenter, open-label study. Eighty patients were enrolled in the safety analysis of the test drug, and 54 of the 80 patients in the efficacy analysis. The efficacy rate based on the number of cases graded as "moderate improvement" or better in the final global improvement rating of the 54 cases included in the efficacy analysis, was 88.9% (95% CI: 77.4-95.8%). Significant improvement in erythema, thickness, and scaling was observed from 2 weeks of treatment onward (p < 0.001). Five local adverse reactions (2 events of irritation, 2 events of itching, and 1 event of redness) were observed in 3 of the 80 patients included in the safety analysis. There were no significant changes in mean serum calcium values. Tacalcitol 20 mug/g ointment is concluded to be effective and safe for the treatment of refractory psoriasis vulgaris with low response to topical corticosteroids.
Keywords : high-concentration tacalcitol ointment, low response to corticosteroids, psoriasis vulgaris, vitamin D3.

High-concentration (20 mug/g) tacalcitol ointment therapy on refractory psoriasis vulgaris with low response to topical corticosteroids