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Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population
European Journal of Dermatology. Volume 12, Number 6, 540-2, November - December 2002, Rapports d'investigature
Free Article
Author(s) : Paola BORGIANI, Laura VALLO, Maria Rosaria D'APICE, Emiliano GIARDINA, Sabina PUCCI, Francesca CAPON, Steven NISTICÒ, Sergio CHIMENTI, Francesco PALLONE, Giuseppe NOVELLI
Summary : Psoriasis is a chronic inflammatory skin disorder showing multifactorial inheritance. Linkage studies have mapped disease susceptibility loci to several genomic regions, including the chromosome 16 interval that contains the CARD15/NOD2 gene. CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis. To test this hypothesis we studied the distribution of 3 CARD15 SNPs in an Italian case-control data set. We failed to observe any significant difference between patients and controls, thereby excluding the presence of a strong genetic association between CARD15 gene polymorphisms and psoriasis, in the Italian population.
Keywords : psoriasis, Crohn's Disease, CARD15, NOD2, genetic susceptibility, pyrosequencing.

Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population