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Cutaneous necrobiotic xanthogranuloma (NXG) - successfully treated with low dose chlorambucil


European Journal of Dermatology. Volume 11, Number 5, 458-62, September - October 2001, Cas cliniques

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Author(s) : Susana MACHADO, Rosário ALVES, Margarida LIMA, Irene LEAL, António MASSA

Summary : We report a case of necrobiotic xanthogranuloma in a 51 year-old white male patient presenting with a 6-year history of multiple indurated violaceous nodules and plaques involving the eyelids, trunk and extremities. He had an associated paraproteinemia (Ig G lambda), elevated sedimentation rate, cryoglobulinemia and hypocomplementemia. No extracutaneous involvement was detected. He was successfully treated with chlorambucil (2 mg/d for 7 months), leading to disappearance of all skin lesions.

Keywords : necrobiotic xanthogranuloma, paraproteinemia

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