Diagnosis: malignant metastatic melanoma presenting with generalized melanosis and melanuria

European Journal of Dermatology. Volume 11, Number 5, 477-8, September - October 2001, Votre diagnostic !

Author(s) : Luigi IULIANO, Angela GURGO, Guglielmo PRANTEDA, Institute of Clinical Medicine I, Università "La Sapienza", Via del Policlinico Umberto I, 165, 00185 Rome, Italy.

Summary : A 62-year-old man was admitted to the Clinic because of a two month history of increasingly weakness. Two weeks before, the patient had developed a progressive gray-blue skin discoloration (Fig. 1). He had also recently noticed darkening of his urine which appeared amber in colour when freshly voided but turned in black on exposure to air (Fig. 2).

Pictures


		Figure 1. Diffuse gray-blue discoloration of the skin.


		Figure 2. Coffee-like urine produced by the patient.


		Figure 3. Pigmented lesion of the lower right eyelid. Note discoloration of the sclerae.