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Evidence of in situ cytotoxicity in American cutaneous leishmaniasis |
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European Journal of Dermatology. Volume 12, Number 5, 449-51, September - October 2002, Rapports d'investigature |
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 Free Article
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Author(s) : Paulo MACHADO, Jean KANITAKIS, Roque ALMEIDA, Aurelie CHALON, Cibele ARAÚJO, Edgar M. CARVALHO |
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Summary : The role of cytotoxicity in the defense mechanisms or pathogenesis of human cutaneous leishmaniasis is not yet well known. In the present work we assessed the presence of NK, CD8+ and CD45RO+ T cells, as well as the expression of a molecule associated with cytotoxic properties (TIA-1) in the lesions of cutaneous leishmaniasis. CD8+ T cells, NK and activated T cells were found within the dermal cell infiltrate. We found a heterogeneous but usually strong expression of TIA-1, a marker of cytotoxic granules of T and NK cells, in human cutaneous leishmaniasis lesions. These data suggest that cytotoxic activity occurs in situ in American cutaneous leishmaniasis and that both NK cells and activated CD8+ T cells are involved in this reaction. |
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Keywords : American cutaneous leishmaniasis, cytotoxicity, immunohistochemistry, leishmaniasis, NK cells, TIA-1. |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés