John Libbey Eurotext




Androgen-independent prostate carcinoma and androgen-receptor: recent progress in molecular genetics
Bulletin du Cancer. Volume 86, Number 7-8, 618-21, Numéro double 7 - 8, Juillet - Août 1999, Point sur…
Résumé Article gratuit
Author(s) : Charles Sultan, Béatrice Terouanne, Bouchra Tahiri, Serge Lumbroso, Christophe Avances, Francesco Orio Jr
Summary : Prostate cancer is an androgen-dependant tumor which presents an androgen-independant regrowth after clinical regression in response to antiandrogen treatment. Four hypotheses have been developped to understand how androgen signal transduction pathway mediate androgen-independent tumor progression: over expression of the wild-type androgen-receptor gene, androgen-receptor gene mutation, excessive recruitement of transcriptional co-activator ARA-70 and a cross-talk between the androgen-receptor and the growth factor receptor pathways. In this work, C. Sawyers’s group elegantly demonstrates, in LAPC-4 androgen-independent prostate cancer sublines, that forced hyperexpression of HER-2/Neu receptor thyrosine kinase allowed androgen-independent growth, that HER-2/Neu activated the androgen-receptor pathway in the absence of androgens and synergized with low levels of androgen to superactivate the pathway. These important data could have therapeutic implications for the management of androgen-independant prostate cancer.
Keywords : prostate cancer, androgen-independent growth, growth factor, HER-2/Neu receptor tyrosine kinase.

Androgen-independent prostate carcinoma and androgen-receptor: recent progress in molecular genetics