John Libbey Eurotext




Effects of oral contraceptive preparations and smoking on lipoprotein repartition
Annales de Biologie Clinique. Volume 57, Number 5, 573-8, Septembre - Octobre 1999, Articles originaux
Résumé Article gratuit
Author(s) : T. Foulon, N. Payen, P. Groslambert, S. Bijaoui, G. Dupont, F. Roland, F. Laporte
Summary : We studied the effect of oral contraceptives and smoking on the lipid profile of 251 women and 72 men, 20-29-year-old. In women, taking estroprogestatives, cholesterol, triglycerides, apoproteins AI and B were higher than in controls; HDL-cholesterol was not modified. Lipoprotein analyses in polyacrylamide gradient gel exhibited an increase of the HDL3 fraction at the expense of the HDL2 fraction, with a reduced LDL size. Smoking in addition to estroprogestative absorption accentuated these modifications and led to a decreased HDL-cholesterol (HDL2 fraction essentially), with an increased LDL-cholesterol. In men, smoking resulted in higher levels of total cholesterol, apoprotein B and LDL-cholesterol, without any significant change in LDL size, higher levels of triglycerides and lower level of the HDL2 fraction without any change in HDL-cholesterol. In women, smoking led only to an increase in triglycerides. In summary, analysis of the distribution of HDL subclasses and of LDL size showed an evolution towards a supposed more atherogenic lipid profile in women taking oral contraceptives associated or not with smoking, and in male smokers.
Keywords : Oral contraceptives - Tobacco - Apolipoproteins AI and B.

Effects of oral contraceptive preparations and smoking on lipoprotein repartition