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Méthodes biostatistiques appliquées à la recherche clinique en cancérologie
Biostatistics methods applied in cancerology clinical research
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Coordonné par Andrew Kramar et Simone Mathoulin-Pélissier
2011
Series : L’innovation thérapeutique en cancérologie
Find out the books of L’innovation thérapeutique en cancérologie
ISBN : 978-2-7420-0774-5
384 pages
Specialty : Oncology
Published in : French
Format : 17 x 24 cm
 Sommaire (fr)
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In cancerology, statistical methods are used to summarise the information provided by the collection of data from clinical or observational studies, whether it is to evaluate a new diagnostic test, a new treatment strategy, risk factors or prognostic factors.
To understand these methods, it is essential to have some knowledge of the population involved, the conditions under which the results were obtained and whether these results were correctly interpreted. Statisticians from cancer centres are faced with questions that require increasingly more sophisticated analyses. The aim of this work is to explain the biostatistics methods most commonly used in cancerology.
The authors included some preliminary ideas to grasp statistical variability and descriptive statistics before moving on to the specificity of cancerology. The presentation of hypothetical tests enables the reader to include the steps required for planning a clinical study. The practical aspects that are essential for drafting a statistical analysis plan and statistical report are presented, as are the tools needed to undertake statistical analyses. The emerging fields (Bayesian statistics, phase 0 trials, genomics and genetics) are also included.
Illustrated with a large number of examples, this work will help define statistical requirements in relation to the evaluation of cancerology research projects and will be a reference guide for statisticians working in all fields of oncology.
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