European Cytokine Network
MENUBuprenorphine differentially affects M1- and M2-polarized macrophages from human umbilical cord blood Volume 28, numéro 2, June 2017
Auteurs
Background
Department Of Anesthesiology, Daqing Oil Field General Hospital, NO.9 Saertu District, Daqing City 163000, Heilongjiang Province, China
* Correspondence: Wei Guo. Department Of Anesthesiology, Daqing Oil Field General Hospital, NO.9 Saertu District, Daqing City 163000, Heilongjiang Province, China
a Authors contributed equally
- Mots-clés : buprenorphine, macrophage, IRF5, downregulation, lipopolysaccharide
- DOI : 10.1684/ecn.2017.0392
- Page(s) : 85-92
- Année de parution : 2017
As a partial μ-opioid receptor agonist with long half-life time, buprenorphine has been widely used to relieve chronic cancer and nonmalignant pain. The maintenance of chronic pain involves inflammation; however whether buprenorphine has anti-inflammation property remains unclear.